TRANSLATIONAL PHYSIOLOGY Phosphodiesterase-3 inhibition augments the myocardial infarct size-limiting effects of exenatide in mice with type 2 diabetes
نویسندگان
چکیده
Yumei Ye,* Jinqiao Qian,* Alexander C. Castillo, Shukuan Ling, Hongmei Ye, Jose R. Perez-Polo, Mandeep Bajaj, and Yochai Birnbaum Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas; Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China; Section of Endocrinology, Baylor College of Medicine, Houston, Texas; Section of Cardiology, Baylor College of Medicine, Houston, Texas; and Texas Heart Institute, St. Luke Episcopal Hospital, Houston, Texas
منابع مشابه
Effects of pretreatment with non hypotensive dose of ramiprilat and losartan on myocardial ischemia-reperfusion induced arrhythmias and infarct size in rats
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OBJECTIVE To investigate the cardioprotective effects of isoflurane and exendin-4 against myocardial ischemia/reperfusion injury and the signaling pathways through which these effects are mediated. MATERIALS AND METHODS For infarct size measurements, anesthetized mice were subjected to 30 min of coronary artery occlusion followed by 2 h of reperfusion. Wild-type or caveolin-3 knockout mice re...
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Objective(s): Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on hemodynamic parameters, lipid peroxidation, and infarct size induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated. Materials and Methods: Eighty male Wistar rats (250–300 g) were divided into 8 groups...
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